One person in the team wasn’t able to open an Excel spreadsheet on our SharePoint 2010 server. There were two errors depending on how you tried to open the file.
The first error was shown when the excel spreadsheet was being displayed in the browser and you clicked on the Open In Excel button.
“To open this workbook, your computer must have a version of Microsoft Excel installed and your web browser must support opening files directly from Excel in the browser.”
The second error was seen when trying to Open in Excel from the Document Library view.
“The document could not be opened for editing. A Microsoft SharePoint Foundation compatible application could not be found to edit the document.”
The answer to the problem was that they were using some sort of quick launch application which was always executing the 64 bit version of IE and switching to the 32 bit version worked.